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Price$ 91.50
  • SKU: Z-2609-10MG
  • Pack Size: 10 MG
Quantity
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+

1H-β-D-ribofuranosyl-2-pyrimidinone

3690-10-6

228.2

C9H12N2O5

DMF, DMSO, PBS (pH 7.2)

-20°C


DNA methyltransferase inhibitor which binds covalently to methyltransferases. Re-activates silenced E-cadherin expression in EBV-harboring Burkitt’s lymphoma Akata cells. Delays tumor growth and induces apoptosis in a genetically engineered mouse model of breast cancer. Potentiates differentiation of mesenchymal stem cells into cardiomyocytes. Inhibits cytidine deaminase (Ki ~ 2 μM). Active in vivo.

References:

1. L Zhou et al. J. Mol. Biol. 2002 321:591

2. SP Rao et al. Mol. Cancer 2007 6:3

3. M Chen et al. Mol. Cancer Ther. 2012 11:370

4. N Naeem et al. Cardiovasc. Ther. 2013 31:201

5. J Laliberte et al. Cancer Chemother. Pharmacol. 1992 30:7

0.1 lbs



Research or further manufacturing use only, not for food or drug use.

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